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063460 Introduction and methods Background As conventional LDL-c–lowering therapies do not sufficiently lower LDL-c levels in patients with homozygous familial hypercholesterolemia (HoFH), better therapeutic options are …. The researchers conducted a retrospective cohort study based on data from the U. The increase in prescription of GLP-1RA remained lower (4% in 2016 to 15% in 2021). The reduction in NT-proBNP levels only explained a small part (~10%) of the effect of canagliflozin on hospitalization for HF. Atherogenic dyslipidemia increases CV risk in diabetes patients. EASD 2022 A post hoc analysis showed that semaglutide reduces CV risk across all strata of kidney function and kidney damage in patients with T2DM who are at high CV risk. Kuiper Distinguished Professor of Medicine, Emeritus Professor of Medicine and of Pharmacology and Physiology at the University of Rochester in. Implementing precision health for public health using causal AI. Findings in CV outcome trials demonstrated CV safety, but results for CV efficacy varied [1]. Two experts discuss recent clinical trials of long-term IV iron therapy in patients with heart failure and iron deficiency and talk about how the results of these trials can be translated into daily practice. With technology advancing at a rapid pace, it’s not always easy to know when to upgrade your device. 27, 2023Presented at the ESC Congress 2023 by: Julian Gillmore, MD, PhD - London, UKIntroduction and methodsTransthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed cause of HF. Atrial fibrillation: From risk prediction to clinical outcomes. mens work boots amazon The Insider Trading Activity of PACE GARY W on Markets Insider. sallys san marcos 4% in annualized terms, better than the 1. Hospitalization of patients with acute HF (AHF) serves 2 main goals: excess fluid removal and optimization of guideline-directed medical therapy (GDMT). Michael Miller presents the findings of a prespecified analysis of the REDUCE-IT trial, in which the effect of icosapent ethyl on first and total CV events was investigated in patients with …. Instead, its all about this ideal pace. Secondary imaging endpoints assessed by OCT – maximum lipid arc. Overall, statin therapy was associated with a significant reduction in overall CV outcomes for both men and women. This presentation by Paul Ridker is part of a series titled "Inflammation: The next therapeutic frontier in targeting cardiovascular risk". Age- and sex-standardized overall mortality rates decrease with increasing income, showing about 13 per 1000 person-years (PY. There was a positive association for each 1 g increase in sodium intake and the mean overall CV event rate (0. Joris Holtrop interviews John McEvoy about the study results. AHA 2023 Michael Lincoff focusses in this video on the clinical implications of the results of the SELECT trial. enesco vintage ETFs have inhaled more than $600. Hartshorne-Evans is a heart failure patient and he runs a patient-driven HF charity in the UK. A practical look at cardiorenal protection for CKD in T2D: Applying recent data. 5, 2023Presented at the ESC congress 2023 by: Frederick Raal, MD - Johannesburg, South AfricaIntroduction and methodsLerodalcibep (LIB-003) is a small binding protein that binds to PCSK9. Other top-dollar donors to Trump 47 included Roger William Norman, a Nevada real-estate developer who gave nearly half a million dollars last year to a super …. ® is of benefit to continuing education providers and the laboratory professionals who participate in the. In honor of Mustang's birthday, the pace car will sport a special 60 th anniversary decal recognizing the milestone as will all Ford cars racing in the event. Watch all episodes, answer pre- and …. Kuiper Distinguished Professor of Medicine, Emeritus Professor of Medicine and of Pharmacology and Physiology at the University of …. Available for benchmark products across all CME Group asset classes, this tool gives you a concise view of how put/call option OI is distributed by strike and expiry. You are now leaving PACE-CME and going to a site run by another organization. 7% compared to placebo in patients with ASCVD, ASCVD risk equivalence, or HeHF on maximally tolerated statins. The Medical Record Keeping Course is an intensive two-day CME program designed to help the physician improve charting behavior and documentation in the …. The number of participants alive at each year of age is represented by the n at risk. Small studies suggest omega-3 fatty acids may reduce total apoCIII in the blood plasma in addition to their triglyceride (TG)-lowering effects. GLP-1RAs may result in beneficial effects on renal outcomes, as shown by analyses of secondary endpoints in large trials. Naveed Sattar, MD, PhD (Glasgow, UK) presented SURMOUNT-4 background, rationale design and baseline characteristics, and Louis Aronne, MD (New York, NY, USA) presented SURMOUNT-4 study efficacy and safety results. More investors are swapping cryptocurrencies for stablecoins,. 006 Introduction and methods Background SGLT2 inhibitors …. Patients received 10 weeks of treatment, followed. The PROMINENT trial investigated the effect of pemafibrate on CV outcomes in patients with T2DM, TG 200-499 mg/dL and HDL ≤ 40 mg/dL. 16, 2023 Presented at the EASD annual meeting 2023. 9696Introduction and methodsBackgroundThe recently published CLEAR Outcomes (Cholesterol Lowering via Bempedoic Acid, an ACL-Inhibiting Regimen) trial showed treatment with bempedoic acid reduced the risk of MACE in statin …. Lp(a) as therapeutic target - now and in the future. PACE offers CME that is inherent to good medical practice but is unique in content. Together with Tessa Laubscher and George Bakris, he discusses what medical therapies are recommended according to the ADA/KDIGO Consensus document 2022 for the treatment of this patient. Asking prices for UK homes rose at the highest annual pace in 12 months, driven by more top-of-the-ladder houses coming to market, according to the online sales portal Rightmove. Hypertrophic cardiomyopathy (HCM) is a clinically heterogeneous disease. These courses use pre- and post-tests to measure the acquisition of knowledge. Seventy one patients received ETC-1002 180 mg and 72 patients …. Addition of very low dose anticoagulation with rivaroxaban 2. Cocoa futures hit a new high in New York — topping $11,000 a metric ton — as the pace of processing in chocolate factories holds up even in the face of a global …. cheap glock for sale In the FOREST-HCM CMR sub-study, treatment with aficamten for 48 weeks improved cardiac remodeling and function, and stabilized myocardial fibrosis in patients with oHCM. CEP / CME Helmet Interface PACE In Ear Tip. 5 Things a cardiologist needs to know about GLP-1 RA Prof. Thus, low-grade inflammation appears to be one of the pathways through which diet affects insulin resistance. 5 Things a cardiologist needs to know about diabetes Multiple causal pathways contribute to development of T2DM, thus various processes may be targeted to improve glucose regulation. motley fool all in buy alert reddit 12, 2023Presented at the AHA Scientific Sessions 2023 by: Stefan James, MD, PhD - Uppsala, SwedenIntroduction and methodsThere is a need to improve the management of patients who experienced a myocardial infarction (MI) to prevent the risk of future CV and metabolic events. For more information, please visit the ESC website. Marta Ruiz-Ortega describes the role of vascular calcification and alkaline phosphatase (ALP) in CKD and effects of BET inhibition on vascular. Diabetes is a major risk factor in HF and is strongly linked to progression of the disease. Where do novel therapies targeting the PCSK9 pathway might fit in with regard to the lipid management paradigm? Ann Marie Navar gives an overview on current and future therapies. continuing medical education (CME) opportunities. florence prison run The United Kingdom Prospective Diabetes Study (UKPDS) concluded that tight blood pressure control (BP) in patients with T2DM and hypertension can reduce macro- and microvascular diabetic complications [2]. These data show that the e-counselling programme enhanced efficacy of usual care for hypertension at 12 months. AHA 2023 Is the change in blood pressure that was observed with renal denervation in patients with resistant hypertension on medications durable? Michael Bloch shares the 36-months results of the RADIANCE-HTN TRIO trial. The current findings suggest that high levels of Lp (a) may be of use to identify individuals at increased risk of CV events in patients with established CAD. However, it has never been studied whether these drugs are still effective after many …. Understanding the working mechanism of EPA. AHA 2023 To the suprise of the investigators of the AZALEA-TIMI 71 trial, the Data Safety Monitoring Committe recommended early termination of the phase 2 trial with the FXI inhibitor abelacimab in patients with AF. Sabatine highlights subgroups of high-risk patients who benefit most from treatment with this PCSK9 inhibitor. The overall beneficial effect was mainly driven by a large reduction in haemorrhagic stroke (RR on combined data: 0. Marx is the second part of a series on tackling cardiorenal risk in patients with diabetes. Bohula discussed the details of the CAMELLIA-TIMI 61 trial. CME Collaborations CME Collaborations. QB's Roll Tracker tracks the pace of the current and historical futures roll activity across multiple asset classes. In studies performed in an "ob/ob" mouse model of obesity and mixed hyperlipidemia, ALN-ANG treatment as a single 3 …. 23 “Lowering LDL-c by any means reduces CV events […], but any drug on its own is not going to be enough for high risk patients. [Epub ahead of print] Glucose lowering and vascular benefitsThe idea that hyperglycaemia links diabetes and coronary artery disease was already hypothesised in 1929. Gunnar Henderson cracked a leadoff homer against Pablo Lopez in the bottom of the first, then Anthony Santander tied the score at 2-2 with a solo shot in the …. It is important to identify the etiology in a patient with HCM as it drives the treatment plan for these patients. Learn from expert faculty and …. A post-hoc analysis of the PARAGON-HF trial suggested that sacubitril/valsartan has greater …. LDL-c reduction by walnut diet was more pronounced in men than in women (7. This summary is based on the presentation of Javed Butler, MD (Dallas, TX, US and Jackson, MS, US) at the ACC. 1093/eurheartj/ehad889 Introduction and methods Background The REDUCE-IT trial demonstrated that icosapent ethyl (IPE) reduces …. Deanfield emphasizes the importance of early intervention to prevent T2DM and …. Left ventricular hypertrophy has been recognized as an entity of hypertrophy cardiomyopathy (HCM) for hundreds of years. The number of data compromises through September 2021 has already surpassed the total in 2020. Watch all episodes, answer pre- and post-test questions, and start earning CME credits. There is a need for effective and safe treatment to prevent diabetes and its complications. News - June 30, 2021Presented at the ESC HF 2021 by Ewa Straburzynska-Migaj (Poznan, Poland)Introduction and methodsMany patients with HF also have CKD. At 150 days after injection, reductions of 71% and 81% were observed after the 300 mg and 600 mg doses. EPA-DHA mixtures be explained? Preston Mason shares the results of two in vitro studies, in which the working mechanism of EPA was investigated. Furthermore, BP-lowering treatment resulted in a similar reduced risk among those with or without CVD and irrespective of baseline systolic BP. 23 “We as cardiologists have to recognize that time has come to aggressively lower LDL-c, which we are already doing, but we need to add aggressive reduction of inflammation to that”, says Prof. 8% in October, it crept back up to 3% in November. Prescribing and monitoring novel potassium binders for optimizing RAASi therapy in HF. News - May 16, 2021 Aspirin Dosing: A Patient-centric Trial Assessing Benefits And Long-term Effectiveness Trial (ADAPTABLE) Presented at ACC. HoFH: The need to treat - creating awareness, understanding and insights. 2022 Aug 9;ehac444 [Online ahead of print]. She points out that it is critical to treat obesity. Jeffrey Pace, Software Applications Developer IV, was honored with the 2024 President's Meritorious Service Award for his outstanding contributions to the university. Funding for this educational program was provided by unrestricted educational grants from Amgen & Novo Nordisk A/S. Lessons from the biology of CETP inhibition. Bempedoic acid is an ATP citrate lyase inhibitor …. We apply our academic expertise to improve patient care by providing over 100,000 continuing education credits annually for clients, physicians, and laboratory professionals at no cost, through our online CME, P. Freelancer (and funny guy) Chris Hardwick read and tried Getting Things Done, The 4-Hour Workweek, and Never Check Email in the Morning and reports back which productivity systems. Verma discusses the CV results of clinical trials with GLP-1RAs and how these translate to CV protection in T2DM. News - July 11, 2023 The US Food and Drug Administration (FDA) has approved a label update for inclisiran to include treatment of patients with elevated LDL-c who have an increased risk of heart disease, in addition to diet and statin therapy, for primary prevention of CV events. , MD (Boston, MA, US) at the ACC. 89) for individuals aged <50 years, 1. ESC 2017 Peter Libby, who started basic research on the role of IL-1 in atherogenesis 30 years ago, gives his perspective on the CANTOS results, including the preliminary results that hint at a reduction in cancer fatalities. This phase IV trial compared four RAAS inhibitors, among which two ACE. Deepak Bhatt, MD - New York, NY, USA Introduction and methods Early phase 1 studies have shown that the highly selective aldosterone synthase inhibitor baxdrostat resulted in a sustained, dose-dependent reduction of plasma aldosterone by >70%. This educational activity is intended for an international audience of non-US and non-UK HCPs. Relative difference of -6% in the eGFR <30 group, -6% for in the eGFR ≥30 to <45 group, and -4% in the eGFR ≥45 …. News - May 22, 2023Presented at ESC Heart Failure 2023 by: Robert Mentz, MD - Durham, NC, USAIntroduction and methodsBackgroundSacubitril/valsartan is recommended by several society guidelines to reduce hospitalizations in HFmrEF and HFpEF. Medicine Matters Sharing successes, challenges and daily happenings in the Department of Medicine Overview of August 5, 2021 Upgrade When: Wednesday, July 28, 2021, 12:00 PM-1:00 P. 24 Scientific Session - Empagliflozin after Acute Myocardial Infarction: Results of the The EMPACT-MI trial. The Commitments of Traders (COT) tool provides a comprehensive and highly configurable graphical representation of the CFTC's report on market open interest released each Friday afternoon based on open positions as of the preceding Tuesday. This summary is based on the publication of Heerspink HJL, Provenzano M, Vart P, et al. Literature - Parikh NI, Gonzalez JM, Anderson CAM et al. Up to 1 full year of access and CME eligibility. Eligible patients were randomized to receive either dietary counseling only (control group; n=1,716) or dietary counseling and ezetimibe 10 mg/day (ezetimibe group; n=1,695) (February 2009 to December 2014), and were followed for 3 years (February 2009. Interesting developments in the field of PCSK9 inhibition. Programs; About Us; Newsletter Subscription; Home; Medical News; Heart Failure; Heart Failure facebook; twitter; linked in; email;. Jukema provides an overview and discusses remaining questions with regard to findings of REDUCE-IT. Follow their LinkedIn page to get updates on their …. Not only to achieve weight reduction, but also to improve health outcomes. What are the characteristics of patients using icosapent ethyl in the real world? Om Ganda shares the results of an analysis that investigated the characteristics of US patients with diabetes who were prescribed icosapent ethyl. Trials have demonstrated that these agents reduce risk of adverse CV events and kidney outcomes n T2DM patients. This is in contrast to the currently available statins and PCSK9 antibodies, that. Literature - Nissen SE, Menon V, Nicholls SJ, et al. The 2019 ESC/EAS dyslipidaemia guidelines recommend an LDL-c treatment goal of<1. The HELIOS trials, a groundbreaking phase 3 program, are investigating the potential of vutrisiran, an RNA interference (RNAi) therapy, to combat both hereditary and wild-type ATTR amyloidosis. Introduction and methods Tirzepatide is a dual GIP and …. Find out how to contact PACE, view their activities, credits, participants, and commercial support status. Henry Ginsberg answers these questions in this video. Andexanet alfa was given conditional approval for the reversal of anticoagulation in life-threatening or uncontrolled bleeding by the US Food and Drug Administration (in 2018) and European Medicines Agency (in 2019); in Japan, full market approval was obtained (in 2022). A total of 714 participants were first randomized to receive either empagliflozin 10 mg or placebo for 8 weeks, they. Steven Hageman interviews Sofian Johar about the new SCORE2-ASIA risk prediction algorithm. The largest increase was seen with prescription of SGLT2i (from 4% in 2016 to 38% in 2021). The inflammatory potential of a diet also seems to affect insulin resistance. Funding for this educational program was provided by an unrestricted educational grant received from AstraZeneca. New insights and guidelines for the management of CKD and diabetes. These results suggest when EPA is combined with DHA, the net impact of higher EPA is blunted by the negative effect of DHA. hue nail bar She substantiates this by summarizing three late-breaking science studies with VERVE-101, lepodisiran and recaticimab. In a total of 16 patients who completed CMR at baseline and at 48 weeks, treatment with aficamten improved LV mass index (-11. - Anticoagulation with edoxaban in patients with long Atrial High-Rate Episodes ≥24 hours. Remotely delivered healthcare could potentially engage more patients in a treatment program. These findings provide support for a scalable. In the past, there has been confusion about the relationship between HDL-c and CV risk and also between triglycerides and CV risk. Study with traditional Chinese medicine in HFrEF: what's the next step? ESC Congress 2023 DICTATE-AHF investigated whether early initiation of dapagliflozin within 24h of AHF hospitalization would improve diuretic efficacy. It needs a single subcutaneous injection and lowers a patient’s LDL-c level for 6 months. The present study identified and validated a metabolic signature reflecting adherence to a Mediterranean diet and examined whether this signature was associated with CVD risk. A dosing of 50 mg asundexian did however reduce recurrent symptomatic ischemic strokes. 73m2 and a urinary albumin-to-creatinine ratio (UACR) of 200-5000 mg/g. This course consists of 4 episodes. Icosapent ethyl has been indicated as an adjunct to maximally tolerated statin therapy in adults with elevated triglyceride levels and CVD or DM with at least two additional CV risk factors to reduce risk of CV events. - Safety Indicators in Patients Receiving High-intensity Care After Hospital Admission for Acute Heart Failure: The STRONG-HF Trial. PACE is a provider of accredited CE/CME activities for various specialties and topics. Literature - Raal F, Durst R, Bi R, et al. Endurance athletes were previously found to …. Time your calendar roll with QB's Roll . Therefore, efficacy and safety of treatment with evolocumab in patients with MetS was evaluated in a subanalysis of the FOURIER trial. However, CME is deeply concerned about the pace of implementation of previously announced measures, compounded by the chilling impact on manufacturing investment through increased capital tax. We've got to use combination therapies and it’s great to have all these different options, which we …. Worldwide, an estimated 850 million people have some form of kidney disease. Eur Heart J 2016; April 26, published online ahead of print It has never been proven that non-fasting lipid profiles are non-superior over fasting lipid profiles. One of the key advantages of using Medscape CME. Improving the management of patients with atherosclerotic cardiovascular disease - The evolving role of icosapent ethyl. 09:45 - 10:30 WEST We’re glad to see you’re enjoying PACE-CME. Your professional development is critical to the care of your patients. Inclisiran was approved by the FDA in December 2021 to lower LDL-c in …. Larger, multicenter cohort studies did not confirm the higher rates of. ®, and Florida continuing education courses. Learning Objectives Educational Objectives Describe the impact of obesity as both an …. ESC Congress 2023 The results of the INTERASPIRE survey call for action to improve secondary prevention of CHD globally. He presents a case of a patient with T2DM and multiple CV risk factors. 0001 and after multivariable adjustment 0. News - May 25, 2019 Presented at ESC Heart Failure 2019 in Athens, Greece, by Patrick Rossignol Vandoeuvre Les Nancy, France Introduction and methods The PATHWAY-2 trial demonstrated that spironolactone was the most effective add-on drug in patients with resistant hypertension. 23 Eugene Yang discusses the results of the CLEAR Outcomes trial and talks about the strengths and limitations of the study. Looking at the LDL-c data by the Friedewald method, a similar pattern was observed (43% reduction in the 5 mg group and 46% in the 10. In the fast-paced world of medicine, staying up-to-date with the latest research and knowledge is crucial for healthcare professionals. Bhatt gives a recap of the findings of the main REDUCE-IT trial with icosapent ethyl and of subsequent analyses. Outcomes of GLP-1 RA in Diabetes & CVD: What are the key opportunities for cardiology practice? Diabetes & CVD: Time for a multifactorial approach. Diagnostic management of acute pulmonary embolism: a prediction model based on a patient data meta-analysis Literature - Van Es N, Takada T, Kraaijpoel N, et al. John McMurray, MD – Glasgow, UKIntroduction and methodsThere was a concern that sacubitril/valsartan might impair cognitive function. Ezetimibe, an inhibitor of cholesterol absorption in the intestine, was used to lower LDL-c. Clinical trials have demonstrated that more …. Stroes describes the 3 pathways involved in progression of atherosclerosis and new algorithms to reduce residual risk with personalized therapy. It remains unknown whether the beneficial effects of the SGLT2i empagliflozin are modified by the presence or absence of AF in patients with HFpEF. This phase 2 proof-of-concept trial showed that ETC-1002 120 mg gives significant LDL-c lowering in hypercholesterolaemic patients with T2DM at day 29, as compared with placebo. pace and on your own time while earning CME credit; Earn up to 20. 3, 2019Among the five new ESC guidelines presented at this year’s ESC congress, was the 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. These data support calls for population-wide intervention to reduce dietary salt intake, not only for its beneficial effect on renal/CV morbidity/mortality, but also for its beneficial effect on therapy response to RAAS intervention. 01) was seen, resulting in an overall reduction of CV death of 14% (HR 0. In patients with apparent resistant hypertension, sacubitril/valsartan reduced SBP to a greater extent than valsartan. 13, 2023 Presented at the ESC congress 2023 by: George Bakris, MD - Chicago, IL, USA Introduction and methods Zilebesiran is a RNA interference therapeutic that inhibits the synthesis of hepatic angiotensinogen. Meeting report with presentation slides, videos and online CME of the EBAC-accredited symposium held at ESC Preventive Cardiology 2023, Malaga, Spain. Boniface Hospital, Winnipeg, CA. 28, 2022Presented at the ESC congress 2022 by: Prof. PACE is a partner for advancing clinical education that offers enduring materials courses and joint providership for continuing medical education (CME). Programs; Live Events; About Us; Newsletter Subscription; We’re glad to see you’re enjoying PACE-CME. Included in Fellow Plus and Premium membership. In patients with an AMI, empagliflozin treatment initiated within 72 hours after PCI was associated with a greater NT-proBNP reduction over 26 weeks compared with placebo. AHA 2021 It is not clear yet what the effect of aspirin is on the risk of dementia in patients with T2DM. Solomon summarizes the results of the DELIVER trial. The framework in these guidelines is used to calculate risk using the pooled …. Dialogue on how to overcome clinical inertia with regard to SGLT2i. Literature - Wang N, Harris K, Hamet P, et al. Bailey briefly summarises the available therapeutic options. Building on a successful phase 1 study demonstrating vutrisiran's safety and effectiveness in reducing serum TTR, HELIOS is paving the way for a new era in …. 23/WCC by: Neha Pagidipati, MD - Durham, NC, USAIntroduction and methodsA recent study showed that high-intensity statins, ACEi/ARBs and SGLT2i or GLP-1RAs are underused in clinical practice, despite proven benefits in patients with T2DM and ASCVD, and recommendations for these agents in …. HFpEF: What are the most likely pathophysiological mechanisms involved in the disease. AHA 2023 "This is such a fascinating time in lipid therapeutics," says Karol Watson. 26, 2022Presented at the ESC congress 2022 by: Prof. He also discusses the challenges in determining Lp (a), the rationale for risk thresholds and whether genetic testing is necessary. The prevalence of diabetes is around 35-40% in patients with HF. Food and Drug Administration (FDA), European Medicines Agency (EMA) and several other regulatory authorities worldwide have approved linagliptin for the treatment of adults with T2D as. vintage aesthetic ipad wallpaper 037076Introduction and methodsThe oral hypoglycemic agents SGLT2-inhibitors act primary by increasing urinary excretion of glucose, but treatment with empagliflozin has also been associated with weight loss and reduction in …. SGLT2i in CKD: How to overcome clinical inertia? Practical challenges with SGLT2i therapy in patients with T2DM and CKD. Pri-Med helps you keep pace with your continuing education so you can focus on providing the best care to your patients. Identifying and treating classic CV risk factors is important in patients with diabetes to reduce their CV risk. Global consumption of jet fuel and kerosene fell to 4. News - May 19, 2021A Novel Physical Rehabilitation Intervention for Older Patients with Acute Decompensated Heart Failure: The REHAB-HF TrialPresented at ACC. 0010) and 36 less minutes sleep per night (95%CI 22-50, P<0. Further research should shed light on whether low-grade inflammation mediates the association between diet and the development of type 2 diabetes. Literature - Dawwas GK, Leonard CE, Lewis JD, et al. PCSK9 Inhibition & CV Outcomes: Review of Lipid Targets and Treatment Strategies. The aim of this study to compare the effectiveness and safety of apixaban and rivaroxaban in patients with AF. What is the totality of evidence for IV iron treatment outcomes in patients with HF? Dr. What is the evidence from IV iron trials in patients with HF suggesting? Marco Metra discusses the recent updates to the ESC HF guidelines and provides an expert analysis regarding clinical trials using IV iron. Lp (a): from causality to therapy. A total of 41 patients (mean age 56 years, 59% female) with symptomatic non-obstructive HCM (NYHA class II/III, LVEF ≥ 60%, NT-proBNP >300 pg/mL) entered the study. 29, 2020The REDUCE-IT trial previously showed a 25% overall event reduction of the primary endpoint (CV death, MI, stroke, coronary revascularization, unstable angina) in statin-treated patients randomized to icosapent ethyl (IPE), compared with those randomized to placebo. 23 Steven Nissen summarizes the results of the CLEAR Outcomes trial and explains what impact these …. org is a leading international education platform in cardiovascular medicine. This progressive and fatal disease is characterized by the deposit of TTR amyloid, which consists of misfolded TTR aggregates, in the heart. Apr 6, 2023 · During the last few years, results of the first dedicated kidney trials with SGLT2 inhibitors –CREDENCE, DAPA-CKD and EMPA-KIDNEY– were presented and published. The north fork rises in the southern part of Stafford County and flows …. ConclusionBoth low doses of rivaroxaban showed to be effective in reducing cardiac events. The protocol was safe and feasible in a variety of health care settings. Video; facebook; twitter; linked in; email; Faiez Zannad, MD 10' education - May 23, 2016 - ESC HF 2016, Florence, Italy - Faiez Zannad, MD - CHU- Nancy University Nancy, France. Benefit of TTR-stabilizer starts as early as 3 months in transthyretin amyloid cardiomyopathy. In this educational program, three experts discuss the clinical characteristics and pathophysiology of HCM, challenges in the diagnosis and management, and therapeutic options for patients with …. Main resultsPooled results of the clinical trials show that consumption of vegetarian diets was associated with a mean reduction in systolic BP (-4. How will outcomes of ARNI trials impact diagnosis and management of HF? The co-chairs introduce the topic of this symposium by explaining that many novel therapies for HFrEF have resulted in difficulties in decision-making for management of these patients. Deepak Bhatt explore the newer cardiac myosin inhibitors that go beyond traditional medical management for the treatment of hypertrophic cardiomyopathy (HCM) at the cellular level. These findings have implications for the management of residual risk. Novel RNAi therapeutic lowers blood pressure in patients with hypertension. Colchicine fails to reduce perioperative AF or MI in patients undergoing major thoracic surgery. Pace yourself when drinking alcohol. Nicholls discuss the results and implications of the PACMAN-AMI study, that investigated the effect of PCSK9i alirocumab on top of high-intensity statins on coronary plaque characteristics in patients with acute MI. Mikhail Kosiborod presents a case of a 50-year-old patient with T2D, obesity, symptomatic HFpEF and early-stage CKD. 24 - Alexander Fanaroff shares the results of the BE ACTIVE trial, which investigated the long-term effectiveness of gamification, financial incentives, or a combination of both approaches for increasing physical activity in patients at risk for cardiovascular events. It has recently been shown that polymorphisms in the NPC1L1 gene are associated with lower LDL-c levels and a lower cardiovascular (CV) risk. This insight has led to a general perception that high levels of LDL-c are …. Funding for this educational program was provided by an unrestricted educational grant from Boehringer Ingelheim / Lilly. LabCE offers American Society of Clinical Laboratory Science (ASCLS) Professional Acknowledgment for Continuing Education® (P. Innovating science and practice - Broadening the understanding of PCSK9i mAb. Seven trials were identified including 35,752 individual participants from 492 sites across Asia, Europe and North-America. Markets are only included if 20 or more traders hold positions equal …. Literature - Juraschek SP, Miller III ER, Weaver CM, et al. warfarin for stroke prevention in patients with atrial fibrillation (AF) showed that DOACs are as effective as warfarin in …. Post-hoc analyses of fibrate trials suggested that TG lowering in patients with T2DM, mild-to-moderate hypertriglyceridemia and low HDL-c may be beneficial. All doses of MK-0616 lowered free PCSK9 in the blood by more than 90%, compared to baseline. Total LDL particles and small LDL particle number were decreased in the walnut group by 4. Small-interfering ribonucleic acid (siRNA)-based therapies against PCSK9 have emerged as an alternative method to lower LDL-c, which require substantial less injections than therapy with PCSK9 monoclonal antibodies. Windows only: Free application SpeedRead is designed to improve your reading speed and retention by quickly flashing a few words at a time on your screen in quick succession. Professional Acknowledgment for Continuing Education (P. Dapagliflozin reduced the risk of the primary composite endpoint of CV death, HF hospitalization or urgent HF visit, compared to placebo (HR 0. Bakris, MD is Professor of Medicine and Director of the ASH Comprehensive Hypertension Center at the University of Chicago Medicine in Chicago, IL, US. Outcomes were CV and renal effectiveness, safety, healthcare resource. The views expressed in this recording are those of the individual presenter and do not necessarily reflect the views of PACE-cme. ESC Congress 2023 The SCORE2-ASIA algorithm is currently being developed to better predict 10-year CVD risk in the Asian populations. CV risk reduction beyond statin therapy: Exploring the role of icosapent ethyl. A commonly used therapeutic strategy for this condition combines 2 diuretics: a thiazide (or thiazide-like) and loop diuretic. 26, 2019Presented during the AHA Scientific Sessions 2019 by John J V McMurray, (University of Glasgow, Glasgow, United Kingdom). Alshahrani pointed out that 86% …. ACC 2023 After YELLOW I and II, the YELLOW III study has now been conducted in which the effect of evolocumab on plaques was investigated using different imaging techniques. 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society. Introduction and methods Background and aim of the …. - Microplastics and Nanoplastics in Atheromas and Cardiovascular Events. 12, 2018Alirocumab was associated with fewer deaths from any cause among patients who had previously experienced an MI or unstable angina, and this was enhanced in patients who were followed for at least 3 years and those who had an LDL-c of ≥100 mg/dL at baseline. Perspectives on the results of recent clinical outcomes trials with EPA - PACE-CME. In addition, more than 3 times the number of patients treated with semaglutide reached a clinical meaningful reduction in body weight (≥5%) than. Unfortunately, many patients are unable to tolerate statins or maximize statin dose resulting in a high …. Artificial intelligence for the management of HF. A total of 10,497 patients were randomized to. 5 mg twice daily appears to be a. However, patients with eGFR<45 mL/min/1. On Friday night, De La Cruz stole three bases and launched a three-run homer. This summary is based on the publication of de Lemos JA, Linetzky B, le Roux CW, et al. Continuing Medical Education (CME) is the mechanism for the life long learning requirement for every healthcare professional. The recommendations in the 2019 ESC guidelines on management of diabetes and CVD have shifted from a glucose-centric approach towards an event-driven approach. - Circulation 2019; Online published ahead of printIntroduction and methodsAlthough treatment with aspirin is recommended for CV prevention in individuals with atherosclerosis, aspirin reduces risk for major vascular events (myocardial infarction, stroke, or vascular death) by only 12% in primary …. However, CME is deeply concerned about the pace of implementation of previously announced measures, compounded by the chilling impact on manufacturing …. [1] As of the 2020 census, the …. The benefit of ticagrelor was comparable. The longball was his sixth of the year and upped his RBI total to 14. Despite CV risk reduction with LDL-c control with statins, there is a high percentage residual CV risk. - Universal Risk Prediction for Individuals With and Without Atherosclerotic Cardiovascular Disease. He backs up this statement by the results of a recent meta-analysis. LDL-c: new insights into its role as causal risk factor and target for therapy. 11, 2018 The American Heart Association (AHA) and the American College of Cardiology (ACC) updated the 2018 guidelines on the management of blood cholesterol in prevention of CVD. Sacubitril is a neprilysin inhibitor and it was suspected that sustained neprilysin inhibition might lead to accumulation of amyloid β-peptides, as …. lfs6b 8, 2022Presented at the AHA Scientific Sessions 2022 by: Prof. The percentage of patients with decreased maxLCBI 4 mm at 26 weeks was 76%. Marx, he discusses the treatment plan for this patient. Novel opportunities tackling residual cardiovascular risk: The evolving role of triglycerides. 15, 2020The Journal of the American College of Cardiology has published an expert consensus decision pathway (ECDP) on novel therapies for CV risk reduction in patients with T2DM [1]. The 2021 European Society of Cardiology (ESC) and Heart Failure Association (HFA) Guidelines for treatment of Heart Failure were partially presented at the virtual ESC HF Congress. We have recorded a number of our live sessions for on-demand viewing. The multidose study found that both 10 and 20 mg doses of MK-0616 on top of statin therapy reduced LDL-c levels by ~65% at day 14, compared to baseline. 2024 Feb 15:S0002-8703(24)00033-4 [Online ahead of print]. 5 mg twice daily showed a relative increase in clinically evident bleeding in patients receiving dual-antiplatelet therapy, as compared to 2. argus obituary 7 million barrels per day (bpd) in 2020, as activity froze during pandemic lockdowns, down from a peak of 7. Deanfield discusses the changing paradigm for managing cardiometabolic risk in clinical practice by the emergence of diabetes. 0 months with alirocumab plus high-intensity or maximum-tolerated statin therapy, followed by statin monotherapy, had a lower risk of MACE during a median follow-up time of 2. Introduction and methods Background Different risk prediction tools are used in primary …. ESC Heart Failure 2023 Ahmad Masri shares the results of the REDWOOD-HCM Cohort 4 trial, a phase 2 study with aficamten in non-obstructive HCM. The CKD components as well as the cardiovascular components of the primary endpoint contributed to the risk reduction. News - June 8, 2020Life-long genetically driven NLRP3 inflammasome activation associated with mortality: A genetic association study of >500,000 individualsPresented at ERA-EDTA during the virtual meeting by Stefan Schunk (Homburg/Saar, Germany)Inflammation plays a role in the development of CKD and CKD-associated …. Introduction and methods Background Atrial high-rate episodes (AHREs) are typically asymptomatic, …. best avatar in roblox for free 24 Scientific Session – A Selective Aldose Reductase Inhibitor for the Treatment of Diabetic Cardiomyopathy – Primary Results of the Phase 3 Randomized Controlled ARISE-HF Study Introduction and methods Heart failure (HF) is …. For a long time, there were no new developments in the field of chronic kidney disease (CKD), despite the huge burden of this disease with a high morbidity and mortality rate. Five years of PCSK9i - Lessons from practice: Which patients benefit most? Prof. SGLT2 inhibitors have beneficial effects on the risk of …. syx moto 125 parts Ray discusses the importance of dyslipidemia in these patients, the associated CV risk and new medical therapies to reduce this risk. PCSK9: Outcomes and trials in clinical perspective There is still a high (residual) risk for future events in many high risk ASCVD patients, despite maximally tolerated statin therapy. PACE INSTITUTE OF TECHNOLOGY AND SCIENCES (PACE PACE INSTITUTE OF TECHNOLOG. Continuing medical education is a specific form of continuing education that helps healthcare professionals …. Literature - Bethel MA, Patel RA, Merrill P, et al. He discusses the possibilities of ultrasound renal denervation in hypertension care. 4 mg reduced the risk of the primary outcome of CV death, MI, or stroke by 20% in patients with pre-existing CVD and overweight or obesity, compared to placebo. pioneer woman dishes on sale There was no dose-response with milvexian for the primary composite endpoint of symptomatic ischemic stroke or covert brain infarction. That is one of the main messages of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) Guidelines on …. Ray focuses on micro- and macrovascular disease in type 2 diabetes, their implications, their interrelationship and how these risks can be modified by new glucose-lowering agents. The results of this study suggest that the CV benefits of treatment with rosuvastatin for a median of 5. After completing follow-up, control patients crossed over to therapy withdrawal using the same protocol, to increase numbers. Time to reduce implementation gaps of lipid-lowering therapy. As most people regularly consume …. UC San Diego Physician Assessment and Clinical Education (PACE) Program. Teaming up to tackle cardiorenal risk in diabetes - Role of SGLT2i: How to overcome clinical inertia. 8, 2022 Presented at the AHA Scientific Sessions 2022 by: Alexandre Mebazaa, MD - Paris, France Introduction and methods After discharge following hospital admission for acute HF (AHF), patients should be followed up within 1–4 weeks, as recommended by the 2021 ESC Guidelines and 2022 ACC/AHA/HFSA guidelines. The effects of empagliflozin on acute changes in eGFR, in relative terms, varied across key patient subgroups: Relative difference of -7% vs. We want to be a buyer at some point but here's the rubONON On Holding AG (ONON) is a holding company and through its subsidiaries, provides footwear and sports apparel prod. 5% that economists were predicting and the fastest pace in a year. They show beneficial effects of SGLT2 inhibitors in. He provides an overview of clinical trials with SGLT2 inhibitors and current recommendations in guidelines. ESC Congress 2023 What are the main changes in the 2023 update of the 2021 ESC HF guidelines? Theresa McDonagh presents the changes of three updated sections. Explore topics such as dyslipidemia, HCM, ASCVD, and more with experts and case studies. 5 Things a cardiologist needs to know about diabetes Prof. Each one-hour webinar includes a 30-minute presentation on a pediatric clinical guideline and 30 minutes dedicated to real-case. Many patients with heart failure (HF) have …. Armitage presents a study in which this was investigated using data of the ASCEND trial. EAS Congres 2023 Atherosclerosis is more than a lipid-driven disease. Binding to PCSK9 leads to blockage of the interaction between PCSK9 and the LDL receptor (LDLR), prevention of LDLR degradation, …. maaco paint repair The role of ALP as predictor of CV events and vascular calcification in CKD. What are triglyceride-rich lipoprotein (TGRL) remnants? How do TGRL remnants differ from LDL and do these differences make them more atherogenic? Prof. “We believe that these data support the use of SGLT2i as foundational therapy in patients with HF, regardless of care setting or ejection fraction” said Prof. Unfortunately, the majority of high- and very high-risk patients do not achieve guideline recommended LDL-c goals. A mechanism of action animation of SGLT2-inhibition, a diabetes therapy that directly targets glucose by reducing renal glucose reabsorption, independently of beta cell function and insulin resistance. Taylor Swift and Beyoncé raked in concert money in 2023 and this year, superstars Olivia Rodrigo and Bad Bunny are taking the stage as Americans are expected to continue spending on live music. Nevertheless, common underlying etiology can be identified among patients with HCM. PRIME Education is an accredited provider of continuing medical education. Tackling the risk of hyperkalemia through guideline-recommended heart failure therapy. Knop sets out how the various effects of GLP-1 receptor agonists can help in management of T2DM. , - Lancet Diabetes Endocrinol 2021, 9(11):743-754. ge p7 oven heating element This summary is based on the publication of Marfella R, Prattichizzo F, Sardu C, et al. Alkaline phosphatase (ALP) is a potential novel treatment target for CVD in CKD. 10:30 - 11:15 EEST John Deanfield, MD. Which patients to consider for GLP-1RA? 5 Things a cardiologist needs to know about GLP-1RA Prof. Differences between treatment groups were -4. Select programs also carry ANCC contact hours. What are key findings of two CV outcomes trials with icosapent ethyl? Prof. Join more than 155,000 actively . Primary care role in CKD - PACE-CME. 12, 2023Presented at the AHA Scientific Sessions 2023 by: Jeff Healey, MD- Hamilton, ON, CanadaIntroduction and methodsBackgroundSubclinical atrial fibrillation refers to brief episodes of atrial fibrillation which are asymptomatic and detected only with long term continuous monitoring, such as a pacemaker or implanted defibrillator. The DAPA-CKD trial was a double-blind, randomized, placebo-controlled trial of 4304 patients with CKD, defined as an eGFR of 25-75 mL/min/1. Homozygous familial hypercholesterolemia (HoFH) is a genetic condition that is associated with very high levels of LDL-c from birth. ESC Congress 2023 Kausik Ray summarizes the findings of a pre-specified analysis of the CLEAR Outcomes trial in which the efficacy and safety of bempedoic acid was examined in patients with normoglycemia, prediabetes and diabetes. Jukema discusses the use of PCSK9 inhibitors in these high risk patients and the recommendations from international guidelines. Lessons from a trial with colchicine in patients undergoing thoracic surgery. east funeral home texarkana obits The effect of PCSK9 inhibition on reducing MACE in patients with MetS is unknown. Triglyceride-rich lipoproteins and residual CV risk. Tardif summarizes the study design and results of the COLCOT trial, in which colchicine treatment was found to lower a composite endpoint in patients soon after MI. 28, 2023 Presented at the ESC Congress 2023 by: Kausik Ray, MD - London, UK Introduction and methods Patients with diabetes and CVD have greater absolute benefits with the addition of ezetimibe and PCSK9 mAbs to statin therapy. Dyslipidemia Heart Failure Hypertrophic Cardiomyopathy Kidney Disease. Kronenberg talks about the importance of measuring Lp (a) levels. The role for primary care in reducing CV risk in diabetes. The siRNA-therapeutic inclisiran reduces hepatic PCSK9 production resulting in reduced circulating PCSK9 levels [1-2]. Lp (a) and calcification in aortic stenosis. Moreover, additional new analyses showed an association between …. The CAROLINA trial evaluated and compared the effects of linagliptin, a DPP-4 …. A total of 299 patients with acute MI were randomized in a 1:1 ratio to receive either biweekly alirocumab (150 mg) or placebo for 50. Apr 4, 2024 · PACE CME Courses. Invitation to the EBAC-accredited satellite symposium on ‘The Weight of Cardiovascular Risk: Addressing Obesity in Cardiac Patients’, at ESC Preventive Cardiology Congress 2024, Athens, Greece. 2023 Oct 9:S1071-9164(23)00342-1. AHA 2019 The ISCHEMIA trial compared early invasive vs. 27, 2022 Presented at the ESC congress 2022 by: Pardeep Jhund, MD, PhD – Glasgow, UK Introduction and methods Up to 55% of patients with HF may have HFpEF in daily clinical practice. 23 Treatment with anthracyclines may lead to cardiotoxicity. west magnolia charm PCSK9i & LDL-c: Guidelines, Practice & Innovation: Review of facts and opportunities. 22, 2021 Presented at the American Heart Association’s Scientific Sessions 2021 by: Alexander J. Updates in anticoagulation management in AF and VTE. 12, 2023Presented at the AHA Scientific Sessions 2023 by: Christian Ruff, MD- Boston, MA, USIntroduction and methodsA meta-analysis of trials (ARISTOTLE, ENGAGE AF-TIMI 48, ROCKET-AF, RE-LY) examining a DOAC vs. In the single-center TELE-ACS trial, the use of a telemedicine-based approach for the management of post-ACS patients was associated with reductions in hospital readmissions, ED visits, unplanned coronary revascularizations, and patient-reported symptoms compared with standard care. Challenges in ASCVD reduction and TG-related risk. Data breaches are approaching a record high. Prolonged Anticoagulation After Primary PCI for STEMI Does Not Reduce Ischemic Events. January CT, Wann LS, Calkins H, et al. Mach discusses the concepts for lipid lowering treatment as defined in the 2019 ESC/EAS dyslipidemia guidelines. 23, 2021Two randomized phase 3 trials, SURPASS-3 and SURPASS-5 trials, showed that treatment of tirzepatide reduced hemoglobin A1c (HbA1c) and body weight from baseline to week 52 or week 40, respectively. hilltop dr AI's voracious need for computing power is threatening to overwhelm energy sources, requiring the industry to change its approach to the technology, according to Arm Holdings Plc Chief Executive. Introduction and methodsIt has been clearly demonstrated that treatment with lipid lowering agents reduces the risk of atherosclerotic CV events [1-4]. Achieving LDL-c targets is a very important goal in patients at risk of cardiovascular disease. Introduction and methods Aim of the program Hypertension and hypercholesterolemia remain undertreated. Over the past years, several studies have shown that SGLT2i and GLP-1RAs reduce the risk of major adverse CV events (MACE). A vegetarian diet was defined as a diet generally excluding or rarely including meats. Patients with iron deficiency have a …. The primary endpoint was relapse of DCM defined by any 1 of: 1: Reduction in LVEF by >10% and to below 50%, 2: increase in LVEDV by >10% and to above normal range, 3: two-fold rise in NT-pro-BNP and to >400ng/L, 4. Earn CME credits while learning at your own pace. 23/WCC by: Christie Ballantyne, MD - Houston, TX, USA Introduction and methods The current PCSK9 inhibitors have shown to lower LDL-c and reduce risk of ASCVD, but these injectables treatment with access barriers and the need for repeat injections have led to poor adoption. ukrainerealestate.org This recording was independently developed under auspices of PACE-cme. This recording was developed under auspices of PACE-CME. To decrease bleeding events in …. PACE has developed this program to meet the needs of the professional who: Effective March 18, 2020 until further notice, all UCSD PACE Program CME courses have been moved online. Learn from expert faculty and contributors at the University of Utah School of Medicine and ARUP Institute for Learning. HONG KONG, July 13, 2021 /PRNewswire/ -- Endurance RP Limited's ('Endurance Longevity' or the 'Company' and together with its subsidiaries, the 'G HONG KONG, July 13, 2021 /PRNe. Monitoring location 07144780 is associated with a Stream in Reno County, Kansas. What is new in the 2023 ESC Guideline Update regarding iron deficiency in HF? A panel of experts discuss what the updates mean to clinical practice in the use of IV iron therapy. Literature - Zhong VW, Van Horn L, Cornelis MC et al. craigslist en richmond va Vascular calcification in kidney disease: Epigenetics as a novel approach? The role of ALP as predictor of CV events and vascular calcification in CKD. Random assignment to drink coffee was associated with 1,058 more steps per day (95% CI 441-1675, P=0. Reduced long-term CV death and MI with complete multivessel revascularization in STEMI. Find coverage of the latest CV news on PACE-CME. The call comes after the compan The company, CME Group Inc (A).